The analysis of drug formulations used in preclinical studies is needed to ensure appropriate administration regarding solubility and/or stability and to evaluate the homogeneity and stability of the formulation to cover the expected  conditions during preparation, storage, dosing, and shipment.

Methodology

We quickly develop and validate LC/MS or HPLC/UV methods for the analysis of drug content in preclinical formulations (solutions or suspensions) of small molecules under GLP. Common vehicles are methyl cellulose for in vivo studies and DMSO for in vitro studies. The methods are usually carried out under GLP compliance, although simplified studies may also be done.

Turnaround time: 3 weeks