Tissue Kinetics assay in rodents
Aim: To characterize the pharmacokinetics of test compound in a tissue and plasma after single dose administration to rodents.
Background information: Tissue distribution studies provide information on distribution and accumulation of a drug at the site of action. This information may be useful for understanding results from toxicological or pharmacological studies.
Tissue pharmacokinetics in rodents is conducted after single dose administration of the compound by the selected route and vehicle. At time points defined previously, blood samples and tissue are collected from each animal. After tissue homogenization and protein precipitation, compound is determined in brain and plasma by UPLC-MS/MS.
Compound requirement: dependent on species, dose and route
Turnaround time: 3 weeks