WeLab is Transforming Possibilities for Tomorrow
Multiple Own Programs Aimed at Providing New Options for Millions of Patients
Alzheimer
Parkinson
Epilepsy
Huntington's Disease
Multiple Sclerosis
Depression
Neuropathic Pain
Fibromyalgia
Schizophrenia
Amyotrophic Lateral Sclerosis
Diabetic Retinopathy
Migraine
Rett Syndrome
Additions and Eating disorders
Disease-modifying therapies supported on human genetics and novel targets addressing:
Neuronal loss
Neuro-inflammation

We are expert on Sigma
receptors field. There are two sigma receptors, sigma-1 and sigma-2, both are
expressed in the CNS, regulate key aspects of neuronal survival in response to
stress and are associated with various neurological disorders, including
Alzheimer’s disease. Targeting sigma receptors has also emerged as a disease-modifying
therapeutic strategy to prevent neurodegeneration. Moreover, the role of
sigma-1 receptor in neuropathic pain has been widely demonstrated.
Besides sigma receptors, we
are actively working on other targets and permanently exploring new
opportunities relevant for our areas of interest.
PROJECT | Compounds | Hit Finding | Hit to Lead | Lead Optimization | Candidate Profiling | Pre-Clinic Development | Clinical Phase I | Clinical Phase II | Clinical Phase III |
Project | WLB-52862 | |||||||||||||||||| | |||||||||||||||||| | |||||||||||||||||| | |||||||||||||||||| | |||||||||||||||||| | |||||||| | Antiviral | |
Sigma2 | WLB-89462 WLB-89362 | |||||||||||||||||| | |||||||||||||||||| | |||||||||||||||||| | |||||||||| | Neurodegeneration | |||
Sigma1 Agonist | WLB-89134 WLB-87848 | |||||||||||||||||| | |||||||||||||||||| | |||||||||||||||||| | |||||||||| | Neurodegeneration | |||
Sigma2 + Sigma1ag | WLB-89204 WLB89237 | |||||||||||||||||| | |||||||||||||||||| | |||||||||||||||||| | |||||||||| | Neurodegeneration | |||
Sigma2 + A2delta1 | Neurodegeneration | ||||||||
Sigma1an + Sigma2 | WLB-89286 | |||||||||||||||||| | |||||||||||||||||| | |||||||||| | Neuropsychiatry | ||||
Sigma1ag + NET | WLB-77663 WLB-77769 | |||||||||||||||||| | |||||||||| | Neuropsychiatry | |||||
Sigma1an + Opioid | WLB-73502 | |||||||||||||||||| | |||||||||||||||||| | |||||||||||||||||| | |||||||||||||||||| | |||||||||||||||||| | |||||||||||||||||| | Pain | |
Alpha2Delta1 | WLB-74422 WLB86484 | |||||||||||||||||| | |||||||||||||||||| | |||||||||||||||||| | Pain | ||||
LPAR | |||||||||| | Pain |