We perform salt screening studies to identify the most suitable solid form for compound development, considering physicochemical properties, crystallinity, stability, polymorphism and impact on in vivo behaviour. We may fully characterize the free parent form and, working with counterions generally regarded as safe (GRAS), we can use different techniques for the preparation of suitable salts.

The process may sequentially include:

1. Free parent compound Physicochemical Characterization
2. Salt selection according to parent compound properties
3. Salt formation in a wide range of conditions
4. Physicochemical Characterization and polymorph occurrence of the different formed salts

The selection of the best form for development is done according to these studies, the project requirements and often considering too comparative pharmacokinetics in preclinical species.