WELAB BARCELONA

Solubility determination

Solubility is a key physicochemical parameter with a direct effect on oral absorption and the overall developability of any New Chemical Entity

Methodology

  • Kinetic solubility: Assays start from the test compound (TC) pre-dissolved in an organic solvent (typically DMSO). After addition to a buffered aqueous solution the concentration is evaluated by liquid chromatography by fitting into a calibration curve of the TC. Assays may be done individually or in a high throughput format at any pH (typically pH=7.4).
  • Thermodynamic solubility: Thermodynamic assays are equilibrium based and start from the solid form of the TC, which is added to an aqueous buffered solution. After achieving thermodynamic equilibrium the concentration of TC in the supernatant is determined by liquid chromatography by fitting in a calibration curve of the TC.
  • pH-solubility profile: Thermodynamic solubility data at different gastrointestinal pHs may be graphed to help establish the boundaries of best absorption and bioavailability.

Turnaround time: 3 days

Dear colleagues, collaborators, and friends,

After more than 30 years of shared endeavours, in which we have grown personally and professionally, and with our emotions on the surface, we announce the closure of our company. We have travelled together through ups and downs, celebrated successes and overcome challenges as a team.

We extend our deepest gratitude to each of you for your dedication, passion, and commitment to a shared goal: discovering new treatments for the benefit and well-being of patients.

As we bid farewell, let’s cherish the memories we’ve created, the bonds we’ve formed, and the impact we’ve made together. Though our paths may diverge, the spirit of collaboration and camaraderie that defines our community will always endure.

We leave proud of the work accomplished and thank you for being an integral part of our journey, wishing you success in all your future challenges.

With heartfelt appreciation,

Welab’s team

We are proud to announce that Welab is partner of this new EU funded project.

In collaboration with 12 partners from 6 countries, Welab Barcelona is establishing the Antivirus Pandemic Preparedness EuropeAn pLatform (APPEAL), a European research initiative aimed at enhancing preparedness for future pandemics. This EU funded collaboration will establish a comprehensive program for the development of broad-spectrum antiviral drugs within a five year time frame ensuring drug affordability and accessibility to low income countries.
Link to the press release: https://lnkd.in/d-jmV2CS